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pentobarbital will lower the level or effect of nateglinide by affecting hepatic enzyme CYP2C9/ten metabolism. Use Caution/Observe.pentobarbital will lower the level or effect of dienogest/estradiol valerate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Women mustn't decide on estradiol valerate/dienogest as their contr